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Numerical Solution of the Inverse Problem for the Mathematical Model of Cardiac Excitation

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We consider the problem of localizing the region of the heart damaged by myocardial infarct. For the two-dimensional modified FitzHugh–Nagumo mathematical model, this inverse problem involves determining the coefficient dependent on spatial variables for a system of partial differential equations in a region with a localized source of cardiac excitation. Additional dynamical measurements of the potential are carried out on the inner boundary of the region representing the section of the heart and its ventricles by a horizontal plane. Potential measurements on the inner boundary correspond to data obtained from ventricular catheters. A numerical method is proposed for the solution of this inverse problem and results of computer experiments are reported.

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References

  1. J. Sundnes, G. T. Lines, X. Cai, et. al, Computing the Electrical Activity of the Heart, Springer (2006).

  2. R. FitzHugh, “Mathematical models of threshold phenomena in the nerve membrane,” Bull. Math. Biophysics, No. 17, 257–278 (1955).

  3. R. FitzHugh, “Impulses and physiological states in theoretical models of nerve membrane,” Biophysical J., No. 1, 445–466 (1961).

  4. J. Nagumo, S. Arimoto, and S. Yoshizawa, “An active pulse transmission line simulating nerve axon,” Proc. IRE, No. 50, 2061–2070 (1962).

  5. R. R. Aliev and A. V. Panfilov, “A simple two-variable model of cardiac excitation,” Chaos Solutions and Fractals, 7, No. 3, 293–301 (1996).

  6. Y. He and D. E. Keyes, “Reconstructing parameters of the FitzHugh–Nagumo system from boundary potential measurements,” J. Comput. Neuroscience, 23, No. 2, 251–264 (2007).

    Article  MathSciNet  Google Scholar 

  7. A. M. Denisov, E. V. Zakharov, A. V. Kalinin, and V. V. Kalinin, “Numerical method for solving an inverse electrocardiography problem for a quasi stationary case.” J. Inverse and Ill Posed Problems, 20, No. 4, 501–512 (2012).

    Article  MathSciNet  MATH  Google Scholar 

  8. A. M. Denisov and V. V. Kalinin, “Inverse problem for mathematical models of cardiac excitation,” Zh. Vychil. Mat. i Matem. Fiziki, 50, No. 3, 539–543 (2010).

    MathSciNet  MATH  Google Scholar 

  9. A. M. Denisov, E. V. Zakharov, an A. V. Kalinin, “Method to determine the projection of an arrhythmia point focus on the surface of the heart by solving the inverse problem of electrocardiography,” Matem. Modelirovanie, No. 4, 22–30 (2012).

  10. A. M. Denisov, and I. A. Pavel’chak, “Numerical method to determine a localized initial excitation for some mathematical models of cardiac excitation,” Matеm. Modelirovanie, No. 7, 59–66 (2012).

  11. A. Pavel’chak and S. R. Tuikina, “Numerical solution method for the inverse problem of the modified FitzHugh–Nagumo model,” Comput. Math. Model., 23, No. 2, 208–215 (2012).

    Article  MathSciNet  MATH  Google Scholar 

  12. I. A. Pavel’chak and S. R. Tuikina, “Numerical solution of an inverse problem for the modified Aliev–Panfilov model,” Comput. Math. Model., 24, No. 1, 14–21 (2013).

    Article  MathSciNet  Google Scholar 

  13. I. A. Pavel’chak, “Numerical method of determining a localized initial cardiac excitation for the Aliev–Panfilov model from measurements on the inner boundary,” Comput. Math. Model., 25, No. 3, 351–355 (2014).

    Article  MathSciNet  Google Scholar 

  14. A. M. Denisov, E. V. Zakharov, and A. V. Kalinin, “Numerical solution of the localized inverse problem of electrocardiography,” Comput. Math. Model., 26, No. 2, 168–174 (2015).

    Article  MathSciNet  Google Scholar 

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Correspondence to S. I. Solov’eva.

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Translated from Prikladnaya Matematika i Informatika, No. 49, 2015, pp. 22–30.

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Solov’eva, S.I., Tuikina, S.R. Numerical Solution of the Inverse Problem for the Mathematical Model of Cardiac Excitation. Comput Math Model 27, 162–171 (2016). https://doi.org/10.1007/s10598-016-9311-8

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