Skip to main content
Log in

Primary Outcomes for Adults Receiving the Unified Protocol after Hurricane Harvey in an Integrated Healthcare Setting

  • Original Paper
  • Published:
Community Mental Health Journal Aims and scope Submit manuscript
  • 2 Altmetric

Abstract

The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) has demonstrated efficacy for treating anxiety and depression. However, there are limited effectiveness data when conducted in real-world settings with diverse populations, including those with trauma. We evaluated treatment outcomes in a naturalistic, community setting among 279 adults who received UP following Hurricane Harvey. We examined change in overall clinical severity, depression and anxiety symptoms, functional impairment, and baseline outcome predictors (i.e., demographic characteristics, impact from Hurricane Harvey, co-occurrence of depression and anxiety symptoms). Global clinical severity, depression and anxiety symptoms, and functional impairment decreased by end-of-treatment. Participants experienced global symptom improvement to a lesser degree than demonstrated in efficacy trials. Participants who experienced greater storm impact reported larger reductions in anxiety symptoms than those less impacted by Harvey. Further studies evaluating the effectiveness of the UP post-disaster and with diverse samples are needed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Notes

  1. Number of patients who received intervention in Spanish was not recorded.

References

  • Almeida, O. P., Draper, B., Pirkis, J., Snowdon, J., Lautenschlager, N. T., Byrne, G., Sim, M., Stocks, N., Kerse, N., Flicker, L., & Pfaff, J. J. (2012). Anxiety, depression, and comorbid anxiety and depression: Risk factors and outcome over two years. International Psychogeriatrics, 24(10), 1622–1632. https://doi.org/10.1017/S104161021200107X

    Article  PubMed  Google Scholar 

  • Bandelow, B., Michaelis, S., & Wedekind, D. (2017). Treatment of anxiety disorders. Dialogues in Clinical Neuroscience, 9(2), 93–107.

    Article  Google Scholar 

  • Barlow, D. H., Farchione, T. J., Bullis, J. R., Gallagher, M. W., Murray-Latin, H., Sauer-Zavala, S., Bentley, K. H., Thompson-Hollands, J., Conklin, L. R., Boswell, J. F., Ametaj, A., Carl, J. R., Boettcher, H. T., & Cassiello-Robbins, C. (2017a). The unified protocol for transdiagnostic treatment of emotional disorders compared with diagnosis-specific protocols for anxiety disorders: A randomized clinical trial. JAMA Psychiatry, 74(9), 875–884. https://doi.org/10.1001/jamapsychiatry.2017.2164

    Article  PubMed  PubMed Central  Google Scholar 

  • Barlow, D. H., Farchione, T. J., Sauer-Zavala, S., Latin, H. M., Ellard, K. K., Bullis, J. R., Bentley, K. H., Boettcher, H. T., & Cassiello-Robbins, C. (2017b). Unified protocol for transdiagnostic treatment of emotional disorders: Therapist guide. Oxford University Press. https://doi.org/10.1093/medpsych/9780190685973.001.0001

    Book  Google Scholar 

  • Barlow, D. H., Harris, B. A., Eustis, E. H., & Farchione, T. J. (2020). The unified protocol for transdiagnostic treatment of emotional disorders. World Psychiatry, 19(2), 244–245. https://doi.org/10.1002/wps.20748

    Article  Google Scholar 

  • Barlow, D. H., Sauer-Zavala, S., Carl, J. R., Bullis, J. R., & Ellard, K. K. (2013). The nature, diagnosis, and treatment of neuroticism. Clinical Psychological Science, 2(3), 344–365. https://doi.org/10.1177/2167702613505532

    Article  Google Scholar 

  • Bauer, M., Bschor, T., Pfennig, A., Whybrow, P. C., Angst, J., Versiani, M., Möller, H. J., WFSBP Task Force on Unipolar Depressive Disorders. (2007). World federation of societies of biological psychiatry (WFSBP) guidelines for biological treatment of unipolar depressive disorders in primary care. The World Journal of Biological Psychiatry, 8(2), 67–104. https://doi.org/10.1080/15622970701227829

    Article  PubMed  Google Scholar 

  • Berk, M., Ng, F., Dodd, S., Callaly, T., Campbell, S., Bernardo, M., & Trauer, T. (2008). The validity of the CGI severity and improvement scales as measures of clinical effectiveness suitable for routine clinical use. Journal of Evaluation in Clinical Practice, 14(6), 979–983. https://doi.org/10.1111/j.1365-2753.2007.00921.x

    Article  PubMed  Google Scholar 

  • Blake, E. S., & Zelinsky, D. A. (2018). National Hurricane Center Tropical Cyclone Report Hurricane Harvey. National Hurricane Center.

    Google Scholar 

  • Bullis, J. R., Boettcher, H., Sauer-Zavala, S., Farchione, T. J., & Barlow, D. H. (2019). What is an emotional disorder? A transdiagnostic mechanistic definition with implications for assessment, treatment, and prevention. Clinical Psychology: Science and Practice. https://doi.org/10.1111/cpsp.12278

    Article  Google Scholar 

  • Cassiello-Robbins, C., Southward, M. W., Tirpak, J. W., & Sauer-Zavala, S. (2020). A systematic review of unified protocol applications with adult populations: Facilitating widespread dissemination via adaptability. Clinical Psychology Review, 78, 101852. https://doi.org/10.1016/j.cpr.2020.101852

    Article  PubMed  Google Scholar 

  • Cohen, J. (1988). The effect size. Statistical power analysis for the behavioral sciences (pp. 77–83). Lawrence Erlbaum Associates.

    Google Scholar 

  • Dunlop, D. D., Song, J., Lyons, J. S., Manheim, L. M., & Chang, R. W. (2003). Racial/Ethnic differences in rates of depression among preretirement adults. American Journal of Public Health, 93(11), 1945–1952. https://doi.org/10.2105/ajph.93.11.1945

    Article  PubMed  PubMed Central  Google Scholar 

  • Ellard, K. K., Fairholme, C. P., Boisseau, C. L., Farchione, T. J., & Barlow, D. H. (2010). Unified protocol for the transdiagnostic treatment of emotional disorders: Protocol development and initial outcome data. Cognitive and Behavioral Practice, 17(2010), 88–101.

    Article  PubMed  PubMed Central  Google Scholar 

  • Farchione, T. J., Fairholme, C. P., Ellard, K. K., Boisseau, C. L., Thompson-Hollands, J., Carl, J. R., Gallagher, M. W., & Barlow, D. H. (2012). Unified protocol for transdiagnostic treatment of emotional disorders: A randomized controlled trial. Behavior Therapy, 43(3), 666–678. https://doi.org/10.1016/j.beth.2012.01.001

    Article  PubMed  PubMed Central  Google Scholar 

  • Fava, M., Rush, A. J., Alpert, J. E., Balasubramani, G. K., Wisniewski, S. R., Carmin, C. N., Biggs, M. M., Zisook, S., Leuchter, A., How land, R., Warden, D., & Trivedi, M. H. (2008). Difference in treatment outcome in outpatients with anxious versus nonanxious depression: A STAR*D Report. The American Journal of Psychiatry, 165(3), 342–351.

    Article  PubMed  Google Scholar 

  • Gallagher, M. W. (2017). Applications of the unified protocol for transdiagnostic treatment of emotional disorders (p. 111). Oxford University Press.

    Book  Google Scholar 

  • Goodman, W. K., Price, L. H., Rasmussen, S. A., Mazure, C., Delgado, P., Heninger, G. R., & Charney, D. S. (1989). The yale-brown obsessive compulsive scale II. validity. Archives of General Psychiatry, 46(11), 1012–1016. https://doi.org/10.1001/archpsyc.1989.01810110054008

    Article  CAS  PubMed  Google Scholar 

  • Guy, W. (1976). ECDEU Assessment manual for psychopharmacology. Rockville.

    Google Scholar 

  • Hansen, N. B., Lambert, M. J., & Forman, E. M. (2002). The psychotherapy dose-response effect and its implications for treatment delivery services. Clinical Psychology Science and Practice, 9(3), 329–343.

    Article  Google Scholar 

  • Hanson, B., & Young, M. A. (2017). Understanding the impairment associated with depressive symptoms. Journal of Nervous & Mental Disease, 205(8), 600–604. https://doi.org/10.1097/NMD.0000000000000644

    Article  Google Scholar 

  • Hendriks, S. M., Spijker, J., Licht, C. M., Beekman, A. T., Hardeveld, F., de Graaf, R., Batelaan, N. M., & Penninx Penninx, B. W. (2014). Disability in anxiety disorders. Journal of Affective Disorders, 166, 227–233. https://doi.org/10.1016/j.jad.2014.05.006

    Article  PubMed  Google Scholar 

  • Hood, C. O., Southward, M. W., Bugher, C., & Sauer-Zavala, S. (2021). A preliminary evaluation of the unified protocol among trauma-exposed adults with and without PTSD. International Journal of Environmental Research and Public Health. https://doi.org/10.3390/ijerph182111729

    Article  PubMed  PubMed Central  Google Scholar 

  • Karlin, B. E., & Cross, G. (2014). From the laboratory to the therapy room: National dissemination and implementation of evidence-based psychotherapies in the U.S. Department of veterans affairs health care system. American Psychologist, 69(1), 19–33. https://doi.org/10.1037/a0033888

    Article  PubMed  Google Scholar 

  • Kroenke, K., Spitzer, R. L., & Williams, J. B. W. (2001). Validity of a brief depression severity measure. Journal of General Internal Medicine, 16(9), 606–613.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lamers, F., van Oppen, P., Comijs, H. C., et al. (2011). Comorbidity patterns of anxiety and depressive disorders in a large cohort study: The Netherlands study of depression and anxiety (NESDA). The Journal of Clinical Psychiatry, 72(3), 341–348.

    Article  PubMed  Google Scholar 

  • McHugh, R. K., & Barlow, D. H. (2010). The dissemination and implementation of evidence-based psychological treatments. A review of current efforts. American Psychologist, 65(2), 73–84. https://doi.org/10.1037/a0018121

    Article  PubMed  Google Scholar 

  • Muthén, L. K., & Muthén, B. O. (1998-2017). Mplus user’s guide (8th ed.). Muthén & Muthén.

  • O’Donnell, M. L., Lau, W., Chisholm, K., Agathos, J., Little, J., Terhaag, S., & Gallagher, M. W. (2021). A pilot study of the efficacy of the unified protocol for transdiagnostic treatment of emotional disorders in treating posttraumatic psychopathology: A randomized controlled trial. Journal of Traumatic Stress, 34(3), 563–574. https://doi.org/10.1002/jts.22650

    Article  PubMed  Google Scholar 

  • Orengo-Aguayo, R., Stewart, R. W., de Arellano, M. A., Suárez-Kindy, J. L., & Young, J. (2019). Disaster exposure and mental health among puerto rican youths after hurricane maria. JAMA Network Open, 2(4), e192619.

    Article  PubMed  PubMed Central  Google Scholar 

  • Pedersen, G., & Karterud, S. (2012). The symptom and function dimensions of the Global assessment of functioning (GAF) scale. Comprehensive Psychiatry, 53(3), 292–298. https://doi.org/10.1016/j.comppsych.2011.04.007

    Article  PubMed  Google Scholar 

  • Picou, J. S., & Hudson, K. (2010). Hurricane Katrina and mental health: A research note on Mississippi Gulf coast residents. Sociological Inquiry, 80(3), 513–524.

    Article  PubMed  Google Scholar 

  • Sakiris, N., & Berle, D. (2019). A systematic review and meta-analysis of the Unified Protocol as a transdiagnostic emotion regulation based intervention. Clinical Psychology Review. https://doi.org/10.1016/j.cpr.2019.101751

    Article  PubMed  Google Scholar 

  • Salomonsson, S., Santoft, F., Lindsater, E., Ejeby, K., Ljotsson, B., Ost, L. G., Ingvar, M., Lekander, M., & Hedman-Lagerlof, E. (2018). Stepped care in primary care - guided self-help and face-to-face cognitive behavioural therapy for common mental disorders: A randomized controlled trial. Psychological Medicine, 48(10), 1644–1654. https://doi.org/10.1017/S0033291717003129

    Article  PubMed  Google Scholar 

  • Sauer-Zavala, S., Gutner, C. A., Farchione, T. J., Boettcher, H. T., Bullis, J. R., & Barlow, D. H. (2017). Current definitions of “Transdiagnostic” in treatment development: A search for consensus. Behavior Therapy, 48(1), 128–138. https://doi.org/10.1016/j.beth.2016.09.004

    Article  PubMed  Google Scholar 

  • Schwartz, R. C., & Prete-Brown, T. D. (2003). Construct validity of the global assessment of functioning scale for clients with anxiety disorder. Psychological Reports, 92(2), 548–550.

    Article  PubMed  Google Scholar 

  • Spitzer, R. L., Kroenke, K., Williams, J. B. W., & Löwe, B. (2006). A brief measure for assessing generalized anxiety disorder The GAD-7. JAMA Internal Medicine, 166(10), 1092–1097. https://doi.org/10.1001/archinte.166.10.1092

    Article  Google Scholar 

  • Stanke, C., Murray, V., Amlôt, R., Nurse, J., & Williams, R. (2012). The effects of flooding on mental health: Outcomes and recommendations from a review of the literature. PLoS Curr. https://doi.org/10.1371/4f9f1fa9c3cae

    Article  PubMed  PubMed Central  Google Scholar 

  • Steele, S. J., Farchione, T. J., Cassiello-Robbins, C., Ametaj, A., Sbi, S., Sauer-Zavala, S., & Barlow, D. H. (2018). Efficacy of the unified protocol for transdiagnostic treatment of comorbid psychopathology accompanying emotional disorders compared to treatments targeting single disorders. Journal of Psychiatric Research, 104, 211–216. https://doi.org/10.1016/j.jpsychires.2018.08.005

    Article  PubMed  PubMed Central  Google Scholar 

  • Twenge, J. M., & Joiner, T. E. U. S. (2020). Census bureau-assessed prevalence of anxiety and depressive symptoms in 2019 and during the 2020 COVID-19 pandemic. Depress Anxiety, 37(10), 954–956.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Varkovitzky, R. L., Sherrill, A. M., & Reger, G. M. (2018). Effectiveness of the unified protocol for transdiagnostic treatment of emotional disorders among veterans with posttraumatic stress disorder: A pilot study. Behavior Modification, 42(2), 210–230. https://doi.org/10.1177/0145445517724539

    Article  PubMed  Google Scholar 

  • Watts, S. E., Turnell, A., Kladnitski, N., Newby, J. M., & Andrews, G. (2015). Treatment-as-usual (TAU) is anything but usual: a meta-analysis of CBT versus TAU for anxiety and depression. Journal of Affective Disorders, 175, 152–167. https://doi.org/10.1016/j.jad.2014.12.025

    Article  PubMed  Google Scholar 

  • Weisz, J. R., Chorpita, B. F., Frye, A., Yi Ng, M., Lau, N., Kate Bearman, S., Ugueto, A. M., Langer, D. A., Hoagwood, K. E., Research Network on Youth Mental. (2011). Youth Top Problems: using idiographic, consumer-guided assessment to identify treatment needs and to track change during psychotherapy. Journal of Consulting and Clinical Psychology, 79(3), 369–380. https://doi.org/10.1037/a0023307

    Article  PubMed  Google Scholar 

  • Westfall, J. M., Mold, J., & Fagnan, L. (2007). Practice-based research—“Blue Highways” on the NIH roadmap. JAMA, 297(4), 403–406.

    Article  CAS  PubMed  Google Scholar 

  • Williams, D. R., González, H. M., Neighbors, H., Nesse, R., Abelson, J. M., Sweetman, J., & Jackson, J. S. (2007). Prevalence and distribution of major depressive disorder in African Americans, Caribbean Blacks, and Non-Hispanic Whites. JAMA Psychiatry, 64(3), 305–315. https://doi.org/10.1001/archpsyc.64.3.305

    Article  Google Scholar 

  • Wolitzky-Taylor, K., Zimmermann, M., Arch, J. J., De Guzman, E., & Lagomasino, I. (2015). Has evidence-based psychosocial treatment for anxiety disorders permeated usual care in community mental health settings? Behaviour Research and Therapy, 72, 9–17. https://doi.org/10.1016/j.brat.2015.06.010

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

The views expressed are those of the authors alone and do not necessarily reflect views of the Greater Houston Community Foundation, Hurricane Harvey Relief Fund, National Institutes of Health, or Baylor College of Medicine. We acknowledge the contributions of Ms. Maryam Anis, Ms. Stacy Baynham, Ms. Jamie Campos, Dr. Lawrence Chiu, Ms. Cynthia Connor, Dr. Michelle Davis, Ms. Roxanne Deams, Dr. Syed Iqbal, Dr. Natalia Kazakevich, Ms. Margaret Kenney, Ms. Mayra Perez, Ms. Alana Stanley, Dr. Beenish Syed, Mr. Frank Velasquez, and Dr. Lorna Wilks.

Funding

Research reported in this publication was supported by the Greater Houston Community Foundation and the Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health under Award Number P50HD103555 for use of the Clinical and Translational Core facilities. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Eric A. Storch.

Ethics declarations

Confilct of interest

Dr. Storch receives research support from NIH, International OCD Foundation, Greater Houston Community Foundation, Texas Higher Education Coordinating Board, and the Misophonia Research Fund. He has received royalties from Elsevier Publications, Springer Publications, American Psychological Association, Wiley, Inc., Jessica Kingsley, and Lawrence Erlbaum. Dr. Storch is on the Speaker’s Bureau and Scientific Advisory Board for the International OCD Foundation. He owns stock in NView. He is a consultant for Biohaven. Dr. Ehrenreich-May receives financial support for research from NIH, PCORI, the U.S. Department of Defense, the Children’s Trust, the Misophonia Research Fund, and Northwell Health. Dr. Schneider receives grant funding from the Texas Higher Education Coordinating Board, NIH, the American Red Cross, and the Misophonia Research Fund. All other authors report no financial disclosures. We report no other potential conflicts of interest.

Ethical Approval

This research was approved by the Baylor College of Medicine and Harris Health System institutional review boards with a waiver of consent to collect de-identified data. All authors certify responsibility for this manuscript.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Weinzimmer, S.A., Goetz, A.R., Guzick, A.G. et al. Primary Outcomes for Adults Receiving the Unified Protocol after Hurricane Harvey in an Integrated Healthcare Setting. Community Ment Health J 58, 1522–1534 (2022). https://doi.org/10.1007/s10597-022-00967-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10597-022-00967-1

Keywords

Navigation