A series of 1,3,4-thiadiazol-2-amines with substituents containing SO2 group located at position 5 were obtained in good yields (63–81%) by cyclization of aryl(benzyl)sulfonylacetic or aryl(benzyl)sulfonylpropionic acids with thiosemicarbazide in refluxing POCl3.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2022, 58(10), 514–517
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Serkov, S.A., Sigay, N.V., Kostikova, N.N. et al. Synthesis of S-substituted 5-sulfonylmethyl(ethyl)-1,3,4-thiadiazol-2-amines. Chem Heterocycl Comp 58, 514–517 (2022). https://doi.org/10.1007/s10593-022-03121-7
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DOI: https://doi.org/10.1007/s10593-022-03121-7