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An efficient one-pot synthesis of indolyl-4H-chromene derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

A new one-pot three-component reaction for the synthesis of indolyl-4H-chromene derivatives has been developed. The synthesis was achieved by reacting salicylaldehydes, (E)-N-methyl-1-(methylsulfanyl)-2-nitroethenamine, and indoles in the absence of solvent using triethylamine as a catalyst. The final products were isolated by precipitation after the addition of ethanol to the reaction mixture. This transformation involves the formation of indole-substituted chromene ring by creation of two C–C bonds and one C–O bond in a single synthetic operation. This rapid one-pot reaction does not require chromatographic purification and provides the indolyl-4H-chromene derivatives in good yields.

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Dr. P. Narayana Reddy acknowledges the financial support of GITAM University through the GITAM: Research Seed Grants (Ref: F.No 2021/0016). Dr. Pannala Padmaja acknowledges the financial support of Department of Science and Technology through the grant WOS-A (No. SR/WOS-A/CS-2/2019).

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Authors and Affiliations

  1. Department of Chemistry, School of Science, Gitam University, Rudraram, Hyderabad, Telangana, 502329, India

    Muralimohan Gampa & Pedavenkatagari Narayana Reddy

  2. Centre for Semiochemicals, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad, Telanagana, 500007, India

    Pannala Padmaja

  3. Department of Chemistry, Osmania University, Hyderabad, Telangana, 500007, India

    Seema Aravind

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  1. Muralimohan Gampa
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  2. Pannala Padmaja
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  3. Seema Aravind
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Correspondence to Pedavenkatagari Narayana Reddy.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2021, 57(12), 1176–1180

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Gampa, M., Padmaja, P., Aravind, S. et al. An efficient one-pot synthesis of indolyl-4H-chromene derivatives. Chem Heterocycl Comp 57, 1176–1180 (2021). https://doi.org/10.1007/s10593-021-03040-z

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