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Selenophenochromones Selectively Inhibit Human Lung Carcinoma Cells Growth

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Chemistry of Heterocyclic Compounds Aims and scope

Synthetic procedures for the preparation of selenophenochromones by treating ethynyl chromones with selenium halides were elaborated. Methyl 3-bromo-2-(1-hydroxycyclohexyl)-9-oxo-9H-selenopheno[2,3-f]chromene-7-carboxylate exhibits high selective in vitro cytotoxic activity against human lung carcinoma cells A549 and H69 up to 1.2 μM.

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Authors and Affiliations

  1. Latvian Institute of Organic Synthesis, 21 Aizkraukles St, Riga, LV-1006, Latvia

    Jelena Vasiljeva, Ilona Domracheva & Pavel Arsenyan

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  1. Jelena Vasiljeva
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  2. Ilona Domracheva
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  3. Pavel Arsenyan
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Correspondence to Pavel Arsenyan.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2021, 57(7/8), 848–856

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Vasiljeva, J., Domracheva, I. & Arsenyan, P. Selenophenochromones Selectively Inhibit Human Lung Carcinoma Cells Growth. Chem Heterocycl Comp 57, 848–856 (2021). https://doi.org/10.1007/s10593-021-02990-8

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  • DOI: https://doi.org/10.1007/s10593-021-02990-8

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