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Synthesis of novel isoxazole derivatives bearing kojic acid moiety and evaluation of their antimicrobial activity

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Chemistry of Heterocyclic Compounds Aims and scope

A novel series of 3,5-disubstituted isoxazoles bearing kojic acid moiety were synthesized via Cu(I)-catalyzed 1,3-dipolar cycloaddition reaction of terminal alkynes with nitrile oxide formed in situ from the corresponding hydroximoyl chloride. Structures of the synthesized compounds were characterized using spectroscopic analysis data. Antimicrobial activity of the isoxazole conjugates was determined as MIC values by broth microdilution method against different bacteria: Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella typhi, and fungi Candida kefyr. The obtained results revealed notable antibacterial and antifungal activities of the compounds.

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Authors and Affiliations

  1. Department of Chemistry, Payame Noor University, Tehran, P. O. Box 19395-3697, Iran

    Sona Khodabandlou & Mahnaz Saraei

Authors
  1. Sona Khodabandlou
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  2. Mahnaz Saraei
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Correspondence to Mahnaz Saraei.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2021, 57(7/8), 823–827

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Khodabandlou, S., Saraei, M. Synthesis of novel isoxazole derivatives bearing kojic acid moiety and evaluation of their antimicrobial activity. Chem Heterocycl Comp 57, 823–827 (2021). https://doi.org/10.1007/s10593-021-02986-4

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  • DOI: https://doi.org/10.1007/s10593-021-02986-4

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