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Addition reaction of various azoles to perfluoromethyl vinyl ether

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Chemistry of Heterocyclic Compounds Aims and scope

The addition reaction of perfluoromethyl vinyl ether to various azoles – derivatives of pyrrole, imidazole, pyrazole, indole, benzotriazole, carbazole, and triazole has been demonstrated. The reaction conditions depended both on melting point and nucleophilicity of the heterocycle. The obtained products are hydrolytically and thermally stable, have highly lipophilic moiety and can serve as useful precursors in different synthesis of bioactive compounds.

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Authors and Affiliations

  1. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St, Kyiv, 02660, Ukraine

    Kirill I. Petko & Andrey A. Filatov

  2. Enamine Ltd., 78 Chervonotkatska St, Kyiv, 02094, Ukraine

    Andrey A. Filatov

Authors
  1. Kirill I. Petko
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  2. Andrey A. Filatov
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Correspondence to Kirill I. Petko.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2021, 57(6), 666–671

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Petko, K.I., Filatov, A.A. Addition reaction of various azoles to perfluoromethyl vinyl ether. Chem Heterocycl Comp 57, 666–671 (2021). https://doi.org/10.1007/s10593-021-02965-9

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  • DOI: https://doi.org/10.1007/s10593-021-02965-9

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