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Silver-assisted palladium-catalyzed one-pot synthesis of 3-(hetero)arylmethyl derivatives of imidazo[1,2-a]pyridines

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Chemistry of Heterocyclic Compounds Aims and scope

3-(Hetero)arylmethyl derivatives of imidazo[1,2-a]pyridine have been synthesized by a novel one-pot method consisting of the Sonogashira coupling of tert-butyl prop-2-yn-1-yl(pyridin-2-yl)carbamate with different substituted (hetero)aryl bromides and cyclization of the in situ obtained intermediate substituted (hetero)aryl acetylene derivatives.

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The authors thank GVK Biosciences, Hyderabad and Andhra University for providing the facilities to perform the research.

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Authors and Affiliations

  1. Discovery Chemistry Solutions, GVK Biosciences, Nacharam, Hyderabad, Telangana State, 500076, India

    Krishna Chaitanya Kasina, Siva Kumar Rapeti, Arghya Sadhukhan, Mahesh Ranga, Arani Pal & Saritha Birudaraju

  2. Department of Inorganic and Analytical Chemistry, Andhra University, Visakhapatnam, Andhra Pradesh, 530003, India

    Krishna Chaitanya Kasina & Siva rao Tirukkovalluri

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  1. Krishna Chaitanya Kasina
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  2. Siva Kumar Rapeti
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  3. Arghya Sadhukhan
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  4. Mahesh Ranga
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  5. Arani Pal
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  6. Saritha Birudaraju
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  7. Siva rao Tirukkovalluri
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Corresponding authors

Correspondence to Saritha Birudaraju or Siva rao Tirukkovalluri.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2021, 57(5), 548–553

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Kasina, K.C., Rapeti, S.K., Sadhukhan, A. et al. Silver-assisted palladium-catalyzed one-pot synthesis of 3-(hetero)arylmethyl derivatives of imidazo[1,2-a]pyridines. Chem Heterocycl Comp 57, 548–553 (2021). https://doi.org/10.1007/s10593-021-02941-3

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