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Synthesis and antiherpetic activity of novel purine conjugates with 7,8-difluoro-3-methyl-3,4-dihydro-2H-1,4-benzoxazine

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Chemistry of Heterocyclic Compounds Aims and scope

A method for the synthesis of novel purine conjugates with 7,8-difluoro-3-methyl-3,4-dihydro-2H-1,4-benzoxazine containing fragments of ω-amino acids with different lengths of the polymethylene chain as a linker has been developed. It was found in experiments in vitro that the obtained compounds are active against the herpes simplex virus type 1, including the acyclovir-resistant strain.

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Authors and Affiliations

  1. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg, 620108, Russia

    Olga А. Vozdvizhenskaya, Galina L. Levit, Victor P. Krasnov & Valery N. Charushin

  2. D. I. Ivanovsky Institute of Virology, Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 16 Gamaleya St., Moscow, 123098, Russia

    Valeriya L. Andronova & Georgii А. Galegov

  3. Institute of Chemical Engineering, Ural Federal University, 19 Mira St., Yekaterinburg, 620062, Russia

    Victor P. Krasnov & Valery N. Charushin

Authors
  1. Olga А. Vozdvizhenskaya
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  2. Valeriya L. Andronova
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  3. Georgii А. Galegov
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  4. Galina L. Levit
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  5. Victor P. Krasnov
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  6. Valery N. Charushin
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Corresponding author

Correspondence to Victor P. Krasnov.

Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2021, 57(4), 490–497

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Vozdvizhenskaya, O.А., Andronova, V.L., Galegov, G.А. et al. Synthesis and antiherpetic activity of novel purine conjugates with 7,8-difluoro-3-methyl-3,4-dihydro-2H-1,4-benzoxazine. Chem Heterocycl Comp 57, 490–497 (2021). https://doi.org/10.1007/s10593-021-02929-z

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  • DOI: https://doi.org/10.1007/s10593-021-02929-z

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