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Alkaloid-like annulated pyrano[4,3-b]pyrroles: antiviral activity and hydrolysis

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Chemistry of Heterocyclic Compounds Aims and scope

Alkaloid-like angular 6/6/5/6-annulated pyrano[4,3-b]pyrroles (pretazettine analogs) contain chemically labile groups that can react with water at room temperature. Their antiviral activity against Vaccinia virus and their tendency to hydrolysis were investigated. Compounds that were more resistant to hydrolysis exhibited the greatest antiviral activity.

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Authors and Affiliations

  1. Perm State University, 15 Bukireva St., Perm, 614990, Russia

    Ekaterina E. Khramtsova, Maksim V. Dmitriev & Andrey N. Maslivets

  2. State Research Center of Virology and Biotechnology “Vector”, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo, 630559, Novosibirsk Obl., Russia

    Nikolay I. Bormotov, Olga А. Serova & Larisa N. Shishkina

Authors
  1. Ekaterina E. Khramtsova
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  2. Maksim V. Dmitriev
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  3. Nikolay I. Bormotov
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  4. Olga А. Serova
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  5. Larisa N. Shishkina
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  6. Andrey N. Maslivets
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Correspondence to Ekaterina E. Khramtsova.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2021, 57(4), 483–489

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Khramtsova, E.E., Dmitriev, M.V., Bormotov, N.I. et al. Alkaloid-like annulated pyrano[4,3-b]pyrroles: antiviral activity and hydrolysis. Chem Heterocycl Comp 57, 483–489 (2021). https://doi.org/10.1007/s10593-021-02928-0

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  • DOI: https://doi.org/10.1007/s10593-021-02928-0

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