Synthesis of novel 1,4-oxathiine derivatives containing polyfluoroalkyl substituents at positions 2 and 6

Dehydrofluorination of bis(1,1-dihydropolyfluoroalkyl) sulfides with lithium hydroxide in morpholine occurs in a controlled manner with the formation of a new type of bis(enamine) sulfides, bis[2-(morpholin-4-yl)polyfluoroalk-1-en-1-yl]sulfanes, hydrolysis and subsequent fluorination of which leads to the production of novel fluorine-containing 1,4-oxathiine derivatives with divalent sulfur.

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Correspondence to Yaroslav S. Borodkin.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2021, 57(1), 69–74

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Borodkin, Y.S., Shermolovich, Y.G. Synthesis of novel 1,4-oxathiine derivatives containing polyfluoroalkyl substituents at positions 2 and 6. Chem Heterocycl Comp 57, 69–74 (2021). https://doi.org/10.1007/s10593-021-02869-8

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Keywords

  • 1,4-dihydrooxathiines
  • enamines
  • 1,4-oxathianes
  • 1,4-oxathiines
  • sulfides
  • dehydrofluorination