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Synthesis and Evaluation of the Cytotoxicity of Indeno[1,2-c]Isoquinoline Derivatives Bearing Ester Functional Group and 1,2,3-Triazole Moiety

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Chemistry of Heterocyclic Compounds Aims and scope

Synthesis of novel indeno[1,2-c]isoquinoline derivatives, functionalized at the D ring and bearing 1,2,3-triazole unit, has been reported. These hybrid compounds display cytotoxic activity against two human cancer cell lines – KB and HepG2 with half maximal inhibitory concentration (IC50) values in a range of 20–40 μM.

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The authors acknowledge the Vietnamese National Foundation for Science and Technology Development (grant 104.01-2017.27) for financial support.

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Authors and Affiliations

  1. Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet St., Cau Giay, Hanoi, 100000, Vietnam

    Hoai Thu Pham, Giang Le-Nhat-Thuy, Tuyet Anh Dang Thi, Phuong Hoang Thi, Tuan Anh Nguyen, Thanh Ha Nguyen & Tuyen Van Nguyen

  2. Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet St., Cau Giay, Hanoi, 100000, Vietnam

    Giang Le-Nhat-Thuy, Tuyet Anh Dang Thi & Tuyen Van Nguyen

  3. Vietnam University of Traditional Medicine, Ha Dong, Hanoi, 100000, Vietnam

    Tien Dung Nguyen & Hanh Thuong Ngo

  4. VNU University of Science, 19 Le Thanh Tong, Hoan Kiem, Hanoi, 100000, Vietnam

    Tuan Anh Le

Authors
  1. Hoai Thu Pham
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  2. Giang Le-Nhat-Thuy
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  3. Tuyet Anh Dang Thi
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  4. Phuong Hoang Thi
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  5. Tuan Anh Nguyen
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  6. Thanh Ha Nguyen
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  7. Tien Dung Nguyen
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  8. Hanh Thuong Ngo
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  9. Tuan Anh Le
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  10. Tuyen Van Nguyen
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Corresponding author

Correspondence to Tuyen Van Nguyen.

Additional information

Published in Khimiya Geterotsiklicheskikh Soedinenii, 2020, 56(9), 1167–1172

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Pham, H.T., Le-Nhat-Thuy, G., Thi, T.A.D. et al. Synthesis and Evaluation of the Cytotoxicity of Indeno[1,2-c]Isoquinoline Derivatives Bearing Ester Functional Group and 1,2,3-Triazole Moiety. Chem Heterocycl Comp 56, 1167–1172 (2020). https://doi.org/10.1007/s10593-020-02792-4

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  • DOI: https://doi.org/10.1007/s10593-020-02792-4

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