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Novel variants of the multicomponent reaction for the synthesis of 1,2,4-triazolo[1,5-а]pyrimidines and pyrido[3,4-е][1,2,4]triazolo[1,5-а]pyrimidines

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Chemistry of Heterocyclic Compounds Aims and scope

A new multicomponent reaction for regioselective synthesis of substituted 1,2,4-triazolo[1,5-a]pyrimidines using aminotriazoles, β-ketoglutaric acid dimethyl ester, and dimethylformamide dimethyl acetal was implemented. The selective reduction of 1,2,4-triazolo-[1,5-a]pyrimidines to dihydro derivatives and the use of triazolo pyrimidines as starting compounds in multicomponent synthesis of dihydropyrido[3,4-е][1,2,4]triazolo[1,5-a]pyrimidinecarboxylates was demonstrated.

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The study was carried out with a grant from the Russian Science Foundation (project No. 18-74-10097).

The results of the study were partially obtained using the equipment of the Center for Collective Use of the Voronezh State University.

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Authors and Affiliations

  1. Voronezh State University, 1 Universitetskaya Sq, Voronezh, 394018, Russia

    Vladimir А. Polikarchuk, Yuliya V. Chertova, Andrei Yu. Potapov, Irina V. Ledenyova, Yevgeniya А. Kosheleva, Mikhail Yu. Krysin, Oleg А. Kozadyorov, Gennadiy V. Shatalov, Dmitriy Yu. Vandyshev & Khidmet S. Shikhaliev

  2. National Institute of Technology, Mirzapur Part, Kurukshetra, Haryana, 136119, India

    Chetti Prabhakar

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  1. Vladimir А. Polikarchuk
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Correspondence to Mikhail Yu. Krysin or Chetti Prabhakar.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2020, 56(8), 1054–1061

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Polikarchuk, V.А., Chertova, Y.V., Potapov, A.Y. et al. Novel variants of the multicomponent reaction for the synthesis of 1,2,4-triazolo[1,5-а]pyrimidines and pyrido[3,4-е][1,2,4]triazolo[1,5-а]pyrimidines. Chem Heterocycl Comp 56, 1054–1061 (2020). https://doi.org/10.1007/s10593-020-02773-7

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