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A convenient method of synthesis of 8-acyl-2,3,6,7-tetrahydro-5Н-[1,3]thiazolo[3,2-c]pyrimidin-5-ones

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Chemistry of Heterocyclic Compounds Aims and scope

5-Substituted (1,3-thiazolidin-2-ylidene)ketones react regioselectively with 1-chlorobenzyl isocyanates under mild conditions to form diastereomeric 8-acyl-2,3,6,7-tetrahydro-5H-[1,3]thiazolo[3,2-c]pyrimidin-5-ones, the relative configuration of the chiral centers of which was determined by X-ray structural analysis.

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Authors and Affiliations

  1. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv, 02094, Ukraine

    Mariia B. Litvinchuk, Anton V. Bentya, Eduard B. Rusanov & Mikhailo V. Vovk

  2. Lesya Ukrainka Eastern European National University, 13 Voli Ave., Lutsk, 43025, Ukraine

    Nataliia Yu. Slyvka

Authors
  1. Mariia B. Litvinchuk
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  2. Anton V. Bentya
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  3. Nataliia Yu. Slyvka
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  4. Eduard B. Rusanov
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  5. Mikhailo V. Vovk
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Correspondence to Mariia B. Litvinchuk.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2020, 56(1), 101–107

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Litvinchuk, M.B., Bentya, A.V., Slyvka, N.Y. et al. A convenient method of synthesis of 8-acyl-2,3,6,7-tetrahydro-5Н-[1,3]thiazolo[3,2-c]pyrimidin-5-ones. Chem Heterocycl Comp 56, 101–107 (2020). https://doi.org/10.1007/s10593-020-02629-0

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  • DOI: https://doi.org/10.1007/s10593-020-02629-0

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