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Tetrahydroisoquinoline-Based Non-Peptidomimetic Plasmepsin Inhibitors

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Chemistry of Heterocyclic Compounds Aims and scope

A series of tetrahydroisoquinoline derivatives containing different aryl substituents were designed and synthesized using Pictet–Spengler reaction as the key step. The synthesized tetrahydroisoquinoline derivatives displayed micromolar inhibitory activity against plasmepsins I and II.

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Authors and Affiliations

  1. Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga, LV-1006, Latvia

    Linda Kinena & Vita Ozola

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  1. Linda Kinena
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  2. Vita Ozola
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Correspondence to Linda Kinena.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2020, 56(1), 60–66

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Kinena, L., Ozola, V. Tetrahydroisoquinoline-Based Non-Peptidomimetic Plasmepsin Inhibitors. Chem Heterocycl Comp 56, 60–66 (2020). https://doi.org/10.1007/s10593-020-02623-6

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  • DOI: https://doi.org/10.1007/s10593-020-02623-6

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