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Synthesis of Polysubstituted Pyrroles by the Reaction of Enaminoketones, Arylglyoxals, and N,N-Dimethylbarbituric Acid

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Chemistry of Heterocyclic Compounds Aims and scope

Novel pentasubstituted pyrroles containing a propanoic acid fragment in position 1 were obtained by the reaction of arylglyoxals, N,Ndimethylbarbituric and 3-[(4-oxopent-2-en-2-yl)amino]propanoic acids both by sequential introduction of reagents and the one-pot method. The three-component condensation of phenylglyoxal, N,N-dimethylbarbituric acid, and 3-aminocrotonate afforded 3-carboxyethyl-2-methyl-5-phenylpyrrole with a pyrimidine fragment in position 4.

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Authors and Affiliations

  1. V. N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv, 61022, Ukraine

    Nadezhda N. Kolos & Nataliia V. Chechina

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  1. Nadezhda N. Kolos
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  2. Nataliia V. Chechina
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Correspondence to Nadezhda N. Kolos.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2019, 55(12), 1278–1280

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Kolos, N.N., Chechina, N.V. Synthesis of Polysubstituted Pyrroles by the Reaction of Enaminoketones, Arylglyoxals, and N,N-Dimethylbarbituric Acid. Chem Heterocycl Comp 55, 1278–1280 (2019). https://doi.org/10.1007/s10593-019-02613-3

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  • DOI: https://doi.org/10.1007/s10593-019-02613-3

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