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Synthesis of 4-aryl(hetaryl)pyrazolo[1,5-a]pyrazines by palladium-catalyzed Suzuki–Miyaura cross coupling

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Chemistry of Heterocyclic Compounds Aims and scope

4-Bromopyrazolo[1,5-a]pyrazines react with aryl(hetaryl)boronic acids in the presence of catalytic amounts of Pd(dppf)Cl2·CH2Cl2 and an excess of Cs2CO3 in the MeCN–H2O, 9:1 solvent system with the formation of 4-aryl(hetaryl)pyrazolo[1,5-a]pyrazines.

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Authors and Affiliations

  1. National University “Kyiv-Mohyla Academy”, 2 Hrygorija Skovorody St., Kyiv, 04655, Ukraine

    Yevhenii V. Hrynyshyn

  2. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv, 02094, Ukraine

    Yevhenii V. Hrynyshyn, Anna R. Musiychuk, Nazar M. Tsizorik, Andriy V. Bol’but & Mikhailo V. Vovk

  3. Enamine Ltd., 67/45 Chervonotkatska St., Kyiv, 02094, Ukraine

    Andriy V. Bol’but

Authors
  1. Yevhenii V. Hrynyshyn
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  2. Anna R. Musiychuk
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  3. Nazar M. Tsizorik
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  4. Andriy V. Bol’but
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  5. Mikhailo V. Vovk
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Correspondence to Yevhenii V. Hrynyshyn.

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Hrynyshyn, Y.V., Musiychuk, A.R., Tsizorik, N.M. et al. Synthesis of 4-aryl(hetaryl)pyrazolo[1,5-a]pyrazines by palladium-catalyzed Suzuki–Miyaura cross coupling. Chem Heterocycl Comp 55, 1070–1074 (2019). https://doi.org/10.1007/s10593-019-02579-2

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  • DOI: https://doi.org/10.1007/s10593-019-02579-2

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