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New 3,4-bis(indol-1-yl)maleimides as protein kinase inhibitors

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Chemistry of Heterocyclic Compounds Aims and scope

Several previously unknown derivatives of 3,4-bis(indol-1-yl)maleimide, as well as 3-(2,3-dihydroindol-1-yl)-4-(indol-1-yl)maleimide were synthesized as potential analogs for a known series of protein kinase inhibitors BIS I, IV, IX containing the structural motif of 3,4-bis(indol-3-yl)maleimide. The activity of these synthesized compounds was characterized with regard to several human protein kinases and their cytotoxicity was determined.

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Authors and Affiliations

  1. Gause Institute of New Antibiotics, 11 Build. 1 B. Pirogovskaya St, Moscow, 119021, Russia

    Alexey A. Panov & Sergey A. Lakatosh

  2. ProQinase GmbH, Tumor Biology Centre in Freiburg, 117 Breisacher St, 79106, Freiburg, Germany

    Michael H. G. Kubbutat, Frank Totzke & Kristof Schechtel

  3. N. N. Blokhin Russian Cancer Research Center, 24 Build. 2 Kashirskoye Shosse, Moscow, 115478, Russia

    Lyubov G. Dezhenkova

Authors
  1. Alexey A. Panov
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  2. Sergey A. Lakatosh
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  3. Michael H. G. Kubbutat
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  4. Lyubov G. Dezhenkova
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  5. Frank Totzke
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  6. Kristof Schechtel
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Correspondence to Alexey A. Panov.

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Dedicated to the memory of M. N. Preobrazhenskaya

Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2019, 55(11), 1050-1059

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Panov, A.A., Lakatosh, S.A., Kubbutat, M.H.G. et al. New 3,4-bis(indol-1-yl)maleimides as protein kinase inhibitors. Chem Heterocycl Comp 55, 1050–1059 (2019). https://doi.org/10.1007/s10593-019-02576-5

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  • DOI: https://doi.org/10.1007/s10593-019-02576-5

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