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Synthesis of 5-substituted 2-ylidene-1,3-thiazolidin-4-one derivatives and evaluation of their anticancer and antioxidant activities

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Chemistry of Heterocyclic Compounds Aims and scope

Novel 5-(aroyl)methyl- and 5-(aroyl)methylen-2-ylidene-1,3-thiazolidin-4-ones have been prepared in high yields using ketene N,S-acetal salts, obtained from phenyl isothiocyanate and propanedinitrile or ethyl cyanoacetate. Several of the newly synthesized 1,3-thiazolidin-4-one derivatives demonstrate high antioxidant and anticancer activities.

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Authors and Affiliations

  1. Department of Basic Science, Faculty of Oral and Dental Medicine, Nahda University, Beni-Suef, 62511, Egypt

    Khaled F. Saied

  2. Department of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo, 11566, Egypt

    Kamal A. Kandeel

  3. Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt, New Cairo, 11835, Egypt

    Salwa S. Abdelwahab

  4. Department of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef, 62511, Egypt

    Osama M. Ahmed

Authors
  1. Khaled F. Saied
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  2. Kamal A. Kandeel
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  3. Salwa S. Abdelwahab
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  4. Osama M. Ahmed
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Correspondence to Khaled F. Saied.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2019, 55(10), 993–1003

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Saied, K.F., Kandeel, K.A., Abdelwahab, S.S. et al. Synthesis of 5-substituted 2-ylidene-1,3-thiazolidin-4-one derivatives and evaluation of their anticancer and antioxidant activities. Chem Heterocycl Comp 55, 993–1003 (2019). https://doi.org/10.1007/s10593-019-02568-5

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  • DOI: https://doi.org/10.1007/s10593-019-02568-5

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