A reaction of 4-chloropyrazolo[1,5-a]pyrazines with tert-butyl cyanoacetate proceeded via the formation of tert-butyl cyano(pyrazolo- [1,5-a]pyrazin-4(5H)-ylidene)ethanoates as intermediates and led to pyrazolo[1,5-a]pyrazin-4-ylacetonitriles, which were used to obtain derivatives of a new pyrazolo[1,5-a]pyrido[2,1-c]pyrazine system.
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Elemental analysis was performed at the Analytical Laboratory of the Institute of Organic Chemistry, National Academy of Sciences of Ukraine.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2019, 55(9), 893–896
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Tsizorik, N.M., Hrynyshyn, Y.V., Musiychuk, A.R. et al. Synthesis of pyrazolo[1,5-a]pyrazin-4-ylacetonitriles and their annulation with pyridine ring. Chem Heterocycl Comp 55, 893–896 (2019). https://doi.org/10.1007/s10593-019-02554-x
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DOI: https://doi.org/10.1007/s10593-019-02554-x