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One-pot diastereoselective synthesis of functionalized 4,5-dihydropyrroles by reactions of arylglyoxals, β-dicarbonyl compounds, and aromatic amines

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Chemistry of Heterocyclic Compounds Aims and scope

A multicomponent reaction of arylglyoxal hydrates, acetylacetone or acetoacetic ester, aniline or its 3(4)-substituted analogs in 1:1:2 ratio occurred upon stirring in methanol, giving 4-arylamino-5-hydroxypyrroline derivatives containing 4,5-dihydroxypyrrolines as impurities.

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Correspondence to Nadezhda N. Kolos.

Additional information

A Supplementary information file containing the crystal structure parameters for compounds and and experimental details of X-ray structural analysis is available at the journal website

Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2019, 55(9), 827–833

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Kolos, N.N., Karpan, S.A., Omelchenko, I.V. et al. One-pot diastereoselective synthesis of functionalized 4,5-dihydropyrroles by reactions of arylglyoxals, β-dicarbonyl compounds, and aromatic amines. Chem Heterocycl Comp 55, 827–833 (2019).

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