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Synthesis and Antimicrobial Activity of Novel Polycyclic Thienopyridazine Derivatives

A series of novel thienopyridazine derivatives has been synthesized using 9-aminodibenzo[f,h]thieno[2,3-c]cinnoline-8-carbonitrile as starting material. The target products exhibit promising antibacterial and antifungal properties against bacterial strains E. coli, S. aureus, B. subtilis, and K. pneumoniae and fungal strains A. fumigatus and C. albicans. The highest antimicrobial activity against all tested microorganisms demonstrate pyridothienocinnoline derivatives.

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The authors are grateful to the Deanship of Scientific Research of King Saud University for funding in frame of Vice Deanship of Scientific Research Chairs.

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Correspondence to Abd El-Galil E. Amr.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2019, 55(8), 773–778

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Fayed, A.A., Yousif, M.N.M., Abdelgawad, T.T. et al. Synthesis and Antimicrobial Activity of Novel Polycyclic Thienopyridazine Derivatives. Chem Heterocycl Comp 55, 773–778 (2019). https://doi.org/10.1007/s10593-019-02534-1

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  • DOI: https://doi.org/10.1007/s10593-019-02534-1

Keywords

  • pyridothienocinnoline
  • pyrimidothienocinnoline
  • thiazinothienocinnoline
  • thiazolopyrimidothienocinnoline
  • thienocinnoline
  • thienopyridazine
  • triazolopyrimidothienocinnoline
  • antimicrobial agent