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Direct synthesis of N-substituted 1,3-oxazolidines via a hetero-domino Petasis borono-Mannich reaction of 1,2-amino alcohols, formaldehyde, and organoboronic acids

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Chemistry of Heterocyclic Compounds Aims and scope

A simple and convenient approach to the synthesis of N-substituted 1,3-oxazolidines via a hetero-domino Petasis borono-Mannich reaction of 1,2-amino alcohols, formaldehyde, and organoboronic acids has been reported. The transformation provides an effective and complementary pathway toward 1,3-oxazolidine derivatives.

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Financial support for this work from the National Key R&D Program (grant No. 2017YFD0200504), the National Natural Science Foundation of China (grant No. 21572060), the Shanghai Key Laboratory of Catalysis Technology for Polyolefins (LCTP-201301), and the Fundamental Research Funds for the Central Universities is gratefully acknowledged.

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Authors and Affiliations

  1. Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Rd., Shanghai, 200237, China

    Yiting Zheng, Lu Sun, Jiayi Wang & Gonghua Song

Authors
  1. Yiting Zheng
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  2. Lu Sun
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  3. Jiayi Wang
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  4. Gonghua Song
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Corresponding author

Correspondence to Jiayi Wang.

Additional information

Supplementary information file containing 1H and 13C NMR spectral data of compounds 4a–r, 4t, and 4u, is available at the journal website at http://link.springer.com/journal/10593.

Published in Khimiya Geterotsiklicheskikh Soedinenii, 2019, 55(7), 648–653

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Zheng, Y., Sun, L., Wang, J. et al. Direct synthesis of N-substituted 1,3-oxazolidines via a hetero-domino Petasis borono-Mannich reaction of 1,2-amino alcohols, formaldehyde, and organoboronic acids. Chem Heterocycl Comp 55, 648–653 (2019). https://doi.org/10.1007/s10593-019-02511-8

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  • DOI: https://doi.org/10.1007/s10593-019-02511-8

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