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Synthesis of a novel coumarin derivative and its binding interaction with serum albumins

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Chemistry of Heterocyclic Compounds Aims and scope

A novel triazolylcoumarin derivative N-(4-methoxyphenyl)-6-(4-{[(4-methyl-2-oxo-2H-chromen-7-yl)oxy]methyl}-1H-1,2,3-triazol-1-yl)hexanamide was synthesized and its interactions with the transport proteins bovine serum albumin and human serum albumin have been explored by the steady state absorption studies and fluorescence studies at 298 K. The fluorescence spectra show quenching of the tryptophan emission due to the complexation for both protein-ligand complexes. This study reveals appreciable binding of this compound to both proteins, and the values of binding constant are evaluated using different methods. The fluorescence study also helps to get an idea about the change in the microenvironment of the protein upon the ligand binding.

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Authors and Affiliations

  1. Department of Chemistry, Presidency University, 86/1 College St., Kolkata, 700073, India

    Sandip Paul, Raju Ghanti & Anjoy Majhi

  2. Department of Chemistry, Bhawanipur Education Society College, 5 Lala Lajpat Rai Sarani, Kolkata, 700020, India

    Pinki Saha Sardar

Authors
  1. Sandip Paul
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  2. Raju Ghanti
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  3. Pinki Saha Sardar
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  4. Anjoy Majhi
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Corresponding author

Correspondence to Anjoy Majhi.

Additional information

Supplementary information file containing 1H NMR, 13C NMR, and ESI-MS spectra of compound 3 is available at the journal website at http://link.springer.com/journal/10593.

Published in Khimiya Geterotsiklicheskikh Soedinenii, 2019, 55(7), 607–611

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Paul, S., Ghanti, R., Sardar, P.S. et al. Synthesis of a novel coumarin derivative and its binding interaction with serum albumins. Chem Heterocycl Comp 55, 607–611 (2019). https://doi.org/10.1007/s10593-019-02505-6

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  • DOI: https://doi.org/10.1007/s10593-019-02505-6

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