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8-(Methyl(phenyl)sulfonyl)-2,6-dihydroimidazo[1,2-c]- pyrimidin-5(3Н)-ones and 9-(methyl(phenyl)sulfonyl)- 2,3,4,7-dihydro-6H-pyrimido[1,6-a]pyrimidin-6-ones: synthesis and antiviral activity

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Chemistry of Heterocyclic Compounds Aims and scope

A convenient method for the synthesis of novel sulfonic cytosine derivatives, 8-(methyl(phenyl)sulfonyl)-2,6-dihydroimidazo[1,2-c]-pyrimidin-5(3Н)-ones and 9-(methyl(phenyl)sulfonyl)-2,3,4,7-tetrahydro-6H-pyrimido[1,6-a]pyrimidin-6-ones, has been developed based on the reaction of 3-amino-2-(methyl(phenyl)sulfonyl)acrylonitriles with 2-chloroethyl isocyanate and 3-chloropropyl isocyanate. The resulting heteryl sulfones possess antiviral activity.

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Authors and Affiliations

  1. V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, 1 Murmanska St., Kyiv, 02094, Ukraine

    Roman N. Solomyannyi, Olga V. Shablykina, Viktoriia S. Moskvina & Vladimir S. Brovarets

  2. Kyiv Taras Shevchenko National University, 64/13 Volodymyrska St., Kyiv, 01601, Ukraine

    Olga V. Shablykina, Viktoriia S. Moskvina & Volodymir P. Khilya

  3. Institute of Organic Chemistry of the National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv, 02660, Ukraine

    Eduard B. Rusanov

Authors
  1. Roman N. Solomyannyi
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  2. Olga V. Shablykina
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  3. Viktoriia S. Moskvina
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  4. Volodymir P. Khilya
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  5. Eduard B. Rusanov
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  6. Vladimir S. Brovarets
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Correspondence to Viktoriia S. Moskvina.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2019, 55(4/5), 401–407

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Solomyannyi, R.N., Shablykina, O.V., Moskvina, V.S. et al. 8-(Methyl(phenyl)sulfonyl)-2,6-dihydroimidazo[1,2-c]- pyrimidin-5(3Н)-ones and 9-(methyl(phenyl)sulfonyl)- 2,3,4,7-dihydro-6H-pyrimido[1,6-a]pyrimidin-6-ones: synthesis and antiviral activity. Chem Heterocycl Comp 55, 401–407 (2019). https://doi.org/10.1007/s10593-019-02472-y

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  • DOI: https://doi.org/10.1007/s10593-019-02472-y

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