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Pyrrolo[2,3-d]pyrimidine derivatives in the synthesis of a novel heterocyclic system 2a,5a,7-triazaacenaphthylene

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Chemistry of Heterocyclic Compounds Aims and scope

A convenient method for the synthesis of methyl 8-oxo-3H,8H-2a,5a,7-triazaacenaphthylene-2-carboxylate by iodination of 7-allyl-4-methoxypyrrolo[2,3-d]pyrimidine-6-carboxylic acid methyl ester followed by elimination of hydrogen iodide has been developed. The use of 4-methoxypyrrolo[2,3-d]pyrimidine-6-carboxylic acid as the starting compound led to the formation of iodomethylpyrimido[5',4':4,5]-pyrrolo[2,1-c][1,4]oxazine, a promising precursor for the synthesis of a new tricyclic system based on pyrrolo[2,3-d]pyrimidine.

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Authors and Affiliations

  1. V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, 1 Murmanska St, Kyiv, 02094, Ukraine

    Lyubov V. Muzychka, Iryna O. Yaremchuk, Evgenii V. Verves & Oleg B. Smolii

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  1. Lyubov V. Muzychka
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  2. Iryna O. Yaremchuk
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  3. Evgenii V. Verves
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  4. Oleg B. Smolii
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Correspondence to Oleg B. Smolii.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2019, 55(4/5), 397–400

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Muzychka, L.V., Yaremchuk, I.O., Verves, E.V. et al. Pyrrolo[2,3-d]pyrimidine derivatives in the synthesis of a novel heterocyclic system 2a,5a,7-triazaacenaphthylene. Chem Heterocycl Comp 55, 397–400 (2019). https://doi.org/10.1007/s10593-019-02471-z

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  • DOI: https://doi.org/10.1007/s10593-019-02471-z

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