Chemistry of Heterocyclic Compounds

, Volume 55, Issue 4–5, pp 324–332 | Cite as

Recent progress in the synthesis of morpholines

  • Vitalii A. PalchykovEmail author
  • Valentyn A. Chebanov

The morpholine (1,4-oxazinane) motif attracted significant attention due to its widespread availability in natural products and biologically relevant compounds. This review describes recent advances in the synthesis of morpholines and their carbonyl-containing analogs from 1,2-amino alcohols, aziridines, epoxides, and related compounds. Special attention is paid to the syntheses performed in a stereoselective manner and using transition metal catalysis. Selected works published since 2013 are covered.


1,2-amino alcohols aziridines epoxides morpholines 1,4-oxazinanes 



Vitalii A. Palchykov would like to thank SAIA for funding and the National Scholarship Programme of the Slovak Republic for an individual scholarship.


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Oles Honchar Dnipro National UniversityDniproUkraine
  2. 2.State Scientific Institution “Institute for Single Crystals”National Academy of Sciences of UkraineKharkivUkraine

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