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Pd/Cu-assisted C–S activation and N–H insertion: highly versatile synthesis of 2-aminopyrimidines from 3,4-dihydropyrimidine-2(1H)-thiones

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Chemistry of Heterocyclic Compounds Aims and scope

A method for the synthesis of 2-aminopyrimidines from readily available 3,4-dihydropyrimidine-2(1H)-thiones via a palladium-assisted C–S activation and N–H insertion reaction is developed. The process provides an access to a variety of highly diverse 2-aryl(alkyl)-aminopyrimidine adducts in good yields.

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The study was performed with financial support from the SERB, DST-India (project No. ECR/2017/001254).

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Authors and Affiliations

  1. Department of Chemistry, Mohanlal Sukhadia University, Udaipur, Rajasthan, 313001, India

    Hina Mathur, Mohammed Shahrukh Khan Zai, Poonam Khandelwal, Neetu Kumari & Dinesh Kumar Yadav

  2. Department of Chemistry, Banasthali University, Newai, Tonk, Rajasthan, 304022, India

    Ved Prakash Verma

Authors
  1. Hina Mathur
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  2. Mohammed Shahrukh Khan Zai
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  3. Poonam Khandelwal
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  4. Neetu Kumari
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  5. Ved Prakash Verma
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  6. Dinesh Kumar Yadav
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Corresponding author

Correspondence to Dinesh Kumar Yadav.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2018, 54(3), 375–378

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Mathur, H., Zai, M.S.K., Khandelwal, P. et al. Pd/Cu-assisted C–S activation and N–H insertion: highly versatile synthesis of 2-aminopyrimidines from 3,4-dihydropyrimidine-2(1H)-thiones. Chem Heterocycl Comp 54, 375–378 (2018). https://doi.org/10.1007/s10593-018-2276-0

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  • DOI: https://doi.org/10.1007/s10593-018-2276-0

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