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Chemistry of Heterocyclic Compounds

, Volume 54, Issue 2, pp 130–137 | Cite as

Synthesis of spiro[imidazo[2,1-b][1,3]thiazole-6,3'-pyrrolidine] derivatives

  • Lesya M. Saliyeva
  • Nataliia Yu. Slyvka
  • Dmitro A. Mel’nyk
  • Eduard B. Rusanov
  • Ruslan I. Vas’kevich
  • Mikhailo V. Vovk
Article
  • 71 Downloads

6-Arylidene-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5(6Н)-ones reacted with N-alkylazomethine ylides by [2+3] cycloaddition mechanism, resulting in the formation of diastereomeric spiro[imidazo[2,1-b][1,3]thiazole-6,3'-pyrrolidin]-5(6Н)-ones, which were separated by column chromatography.

Keyword

6-arylideneimidazo[2,1-b][1,3]thiazoles azomethine ylides spiro[imidazo[2,1-b][1,3]thiazole-6,3'-pyrrolidines] [2+3] cycloaddition 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Lesya M. Saliyeva
    • 1
  • Nataliia Yu. Slyvka
    • 1
  • Dmitro A. Mel’nyk
    • 2
  • Eduard B. Rusanov
    • 3
  • Ruslan I. Vas’kevich
    • 3
  • Mikhailo V. Vovk
    • 3
  1. 1.Lesya Ukrainka East European National UniversityLutskUkraine
  2. 2.Ivano-Frankivsk National Medical UniversityIvano-FrankivskUkraine
  3. 3.Institute of Organic Chemistry, National Academy of Sciences of UkraineKyivUkraine

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