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Chemistry of Heterocyclic Compounds

, Volume 52, Issue 11, pp 934–942 | Cite as

Heterocyclization Reactions of 3-methylisoxazol-5-amine with Pyruvic Acid Derivatives Using Classical and Non-classical Methods of Activation

  • Alisa D. Morozova
  • Elena A. Muravyova
  • Sergey M. Desenko
  • Vladimir I. Musatov
  • Daria V. Yedamenko
  • Valentin A. ChebanovEmail author
Article

Two- and multicomponent interactions between 3-methylisoxazol-5-amine and pyruvic acid derivatives were studied both by using classical methods of activation, as well as under microwave irradiation and ultrasonication. It was shown that the reactions with esters of arylidene pyruvic acids could lead to the formation of three different types of heterocyclic systems, while in the case of arylidene pyruvic acid a very insignificant conversion of the starting compounds to isoxazolo[5,4-b]pyridine carboxylic acids was observed, due to the low stability of 3-methylisoxazol-5-amine.

Keywords

isoxazolo[5,4-b]pyridine Lewis acid 3-methylisoxazol-5-amine pyruvic acid derivatives ultrasonication heterocyclization microwave irradiation non-classical method of activation 

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Alisa D. Morozova
    • 1
  • Elena A. Muravyova
    • 1
  • Sergey M. Desenko
    • 1
    • 2
  • Vladimir I. Musatov
    • 1
  • Daria V. Yedamenko
    • 1
  • Valentin A. Chebanov
    • 1
    • 2
    Email author
  1. 1.State Scientific Institution “Institute for Single Crystals”National Academy of Sciences of UkraineKharkivUkraine
  2. 2.V. N. Karazin Kharkiv National UniversityKharkivUkraine

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