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Chemistry of Heterocyclic Compounds

, Volume 52, Issue 11, pp 918–922 | Cite as

Reaction of α-tetralone, 1H-tetrazol-5-amine, and aromatic aldehydes upon microwave irradiation – a convenient method for the synthesis of 5,6,7,12-tetrahydrobenzo[h]tetrazolo[5,1-b]quinazolines

Article
A multicomponent reaction between α-tetralone, 1H-tetrazol-5-amine, and aromatic aldehyde, occurring upon microwave irradiation in acidic medium at 130°C, led to the formation of previously unknown 7-aryl-5,6,7,12-tetrahydrobenzo[h]tetrazolo[5,1-b]quinazolines in 5–52% yields.

Keywords

aldehydes tetralone 1H-tetrazol-5-amine Biginelli reaction microwave irradiation multicomponent reactions 

Notes

This work was performed with financial support from the Russian Science Foundation (grant 14-50-00069).

The spectral data (NMR and high-resolution mass spectrometry) were obtained with the equipment at Saint Petersburg State University Research Park ''Research resources center for magnetic resonance'' and ''Center for chemical analysis and materials research''.

Supplementary material

10593_2017_1985_MOESM1_ESM.pdf (1.8 mb)
ESM 1 (PDF 1802 kb)

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Saint Petersburg State UniversitySaint PetersburgRussia

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