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A facile synthesis of N-substituted 2,5-dimethylpyrroles with saccharin as a green catalyst

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Chemistry of Heterocyclic Compounds Aims and scope

The paper describes a convenient method for the preparation of N-substituted 2,5-dimethylpyrroles using edible sweetener saccharin. Various heterocyclic and aromatic hydrazides have been converted to their corresponding Paal–Knorr pyrroles at room temperature in methanol with saccharin as a green catalyst. Saccharin can be recycled for the next two runs without apparent loss in its activity. Here we propose a method which is speedy, proficient, and ecologically safe.

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We gratefully acknowledge the access to laboratory facilities of Manipal Institute of Technology, Manipal.

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Correspondence to Santosh L. Gaonkar.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2015, 51(4), 320–323

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Bhandari, N., Gaonkar, S.L. A facile synthesis of N-substituted 2,5-dimethylpyrroles with saccharin as a green catalyst. Chem Heterocycl Comp 51, 320–323 (2015). https://doi.org/10.1007/s10593-015-1701-x

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  • DOI: https://doi.org/10.1007/s10593-015-1701-x

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