Skip to main content
Log in

Reactivity of Substituted 2-Spiropyrimidin-4-Ones Under Vilsmeier–Haack Conditions

  • Published:
Chemistry of Heterocyclic Compounds Aims and scope

Substituted 2-spiropyrimidin-4-ones are formylated at room temperature under the conditions of the Vilsmeier–Haack reaction. When cautiously heated they undergo electrophilic rearrangement.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others


  1. W. Su, Y. Weng, L. Jiang, Y. Yang, L. Zhao, Z. Chen, Z. Li, and J. Li, Org. Prep. Proced. Int., 42, 503 (2010).

    Article  CAS  Google Scholar 

  2. Q. Li, L. A. Mitscher, and L. L. Shen, Med. Res. Rev., 20, 231 (2000).

    Article  CAS  Google Scholar 

  3. M. Nagarajan, X. Xiao, S. Antony, G. Kohlhagen, Y. Pommier, and M. Cushman, J. Med. Chem., 46, 5712 (2003).

    Article  CAS  Google Scholar 

  4. V. I. Markov, O. K. Farat, S. A. Varenichenko, and E. V. Velikaya, Mendeleev Commun., 22, 101 (2012).

    Article  CAS  Google Scholar 

  5. R. Crossley and R. G. Shepherd, J. Chem. Soc., Perkin Trans. 1, 2479 (1985).

  6. V. I. Markov, O. K. Farat, S. A. Varenichenko, E. V. Velikaya, R. I. Zubatyuk, and O. V. Shishkin, Chem. Heterocycl. Compd., 49, 1158 (2013). [Khim. Geterotsikl. Soedinenii, 1244 (2013)].

    Article  CAS  Google Scholar 

  7. C. Bischoff, E. Schröder, and E. Gründemann, J. Prakt. Chem., 326, 849 (1984).

    Article  CAS  Google Scholar 

  8. G. Zigeuner, W. Adam, and H. Weichsel, Monatsh. Chem., 97, 55 (1966).

    Article  CAS  Google Scholar 

  9. S. Schramm, E. Schmitz, and E. Gründemann, J. Prakt. Chem., 326, 279 (1984).

    Article  CAS  Google Scholar 

  10. V. I. Markov and Yu. Stroev, Voprosy Khimii i Khim. Tekhnologii, 3, 30 (2012).

    Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to S. A. Varenichenko.

Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1743–1748, November, 2014.

Electronic supplementary material

Below is the link to the electronic supplementary material.


(PDF 1222 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Varenichenko, S.A., Farat, O.K. & Markov, V.I. Reactivity of Substituted 2-Spiropyrimidin-4-Ones Under Vilsmeier–Haack Conditions. Chem Heterocycl Comp 50, 1602–1607 (2015).

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: