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Regioselective Synthesis of Pyridin-2-One Derivatives Based on Ethyl(1-Phenylethylidene)- Cyanoacetate and Cyanoacetamides

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Chemistry of Heterocyclic Compounds Aims and scope

Ethyl(1-phenylethylidene)cyanoacetate reacted with cyanoacetamides in alcohol solution of sodium ethoxide, forming various pyridin-2-ones. The cyclization direction of Michael adducts was affected by the nucleophilicity of cyanoacetamide used as a СН acid.

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Correspondence to D. A. Krasnikov.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1228-1231, August, 2014.

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Fefelova, S.R., Krasnikov, D.A., Dyachenko, V.D. et al. Regioselective Synthesis of Pyridin-2-One Derivatives Based on Ethyl(1-Phenylethylidene)- Cyanoacetate and Cyanoacetamides. Chem Heterocycl Comp 50, 1133–1136 (2014). https://doi.org/10.1007/s10593-014-1573-5

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  • DOI: https://doi.org/10.1007/s10593-014-1573-5

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