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8-Alkyl[1,2,4]Triazolo[5,1-b]Purines

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Chemistry of Heterocyclic Compounds Aims and scope

A novel method has been developed for the synthesis of 8-alkyl[1, 2, 4]triazolo[5,1-b]purines from 6-nitro[1,2,4]triazolo[1,5-a]pyrimidin-7-ones via successive phosphoryl chloride-mediated chloro-desoxygenation, aminodehalogenation, and reduction to give 7-alkylamino-6-amino[1,2,4]triazolo-[1,5-a]pyrimidines. The latter can be cyclized in the presence of formic acid.

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Authors and Affiliations

  1. Ural Federal University named after the First President of Russia B. N. Yeltsin, 19 Mir St., Yekaterinburg, 620002, Russia

    K. V. Savateev, E. N. Ulomsky, S. S. Borisov, E. K. Voinkov, V. V. Fedotov & V. L. Rusinov

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  1. K. V. Savateev
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  2. E. N. Ulomsky
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  3. S. S. Borisov
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  4. E. K. Voinkov
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  5. V. V. Fedotov
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  6. V. L. Rusinov
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Correspondence to E. N. Ulomsky.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 953-961, June, 2014.

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Savateev, K.V., Ulomsky, E.N., Borisov, S.S. et al. 8-Alkyl[1,2,4]Triazolo[5,1-b]Purines. Chem Heterocycl Comp 50, 880–887 (2014). https://doi.org/10.1007/s10593-014-1542-z

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  • DOI: https://doi.org/10.1007/s10593-014-1542-z

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