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Synthesis of 1-Adamantyl-3,4,5-R1,R2,R3-Pyrazoles

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Chemistry of Heterocyclic Compounds Aims and scope

A method has been developed for the synthesis of 1-adamantyl-3,4,5-R1,R2,R3-pyrazoles by the reaction of 1,3-dehydroadamantane with N-unsubstituted 3,4,5-R1,R2,R3-1H-pyrazoles in an inert solvent. The effect of the NH acidity (pKa) of the starting 3,4,5-R1,R2,R3-1H-pyrazole on the course of the reaction and the product yields was studied.

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This work was carried out with the financial support of the Russian Ministry of Education and published as the results of the Third International Conference "New Trends in the Chemistry of Heterocyclic Compounds" (17-21 September 2013, Pyatigorsk, Russia).

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Authors and Affiliations

  1. Volzhsky Polytechnic Institute, Branch of the Volgograd State Technical University, 42a Engels St., Volzhsky, 404121, Russia

    G. M. Butov & B. A. Lysykh

  2. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Lenin Ave., Moscow, 119991, Russia

    I. L. Dalinger, I. A. Vatsadze & T. K. Shkineva

  3. Samara State Technical University, 244 Molodogvardeiskaya St., Samara, 443100, Russia

    Yu. N. Klimochkin & V. A. Osyanin

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  1. G. M. Butov
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  2. B. A. Lysykh
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  3. I. L. Dalinger
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  4. I. A. Vatsadze
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  5. T. K. Shkineva
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  6. Yu. N. Klimochkin
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  7. V. A. Osyanin
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Correspondence to G. M. Butov.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 816-820, May, 2014.

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Butov, G.M., Lysykh, B.A., Dalinger, I.L. et al. Synthesis of 1-Adamantyl-3,4,5-R1,R2,R3-Pyrazoles. Chem Heterocycl Comp 50, 752–756 (2014). https://doi.org/10.1007/s10593-014-1530-3

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  • DOI: https://doi.org/10.1007/s10593-014-1530-3

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