Chemistry of Heterocyclic Compounds

, Volume 49, Issue 12, pp 1827–1830 | Cite as

The Synthesis of Benzo[а]Phenazine-5,6-Dione 7-Oxides

  • L. M. GornostaevEmail author
  • T. A. Lyashchenko
  • E. V. Arnold
Letters to the Editor

Tetracyclic nitrogen-containing quinone derivatives exhibit various types of biological activity and show promise for practical applications [1, 2]. Linear and angular quinoid derivatives of benzophenazines are of particular interest. Thus, it was recently discovered that benzo[а]phenazine-5,6-dione derivatives, diimines in particular, may function as ligands for rhodium and ruthenium, and also possess selective anticancer activity [3].

We found that the 4-arylamino-1,2-naphthoquinones - d were converted to the benzo[ а]phenazine-5,6-dione N-oxides - d by treatment with nitrosylsulfuric acid that was prepared in situ from sodium nitrite and sulfuric acid [ 4], and using acetic acid as the solvent.


4-arylamino-1,2-naphthoquinones benzo[а]phenazine-5,6-dione 7-oxides heterocyclization 


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • L. M. Gornostaev
    • 1
    Email author
  • T. A. Lyashchenko
    • 2
  • E. V. Arnold
    • 1
  1. 1.Krasnoyarsk State Pedagogical University named after V. P. Astaf’evKrasnoyarskRussia
  2. 2.Krasnoyarsk State Medical University named after Prof. Voyno-YasenetskyKrasnoyarskRussia

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