Chemistry of Heterocyclic Compounds

, Volume 49, Issue 12, pp 1748–1756 | Cite as

Studies of Imidazo[1,2-a]Benzimidazoles 32*. Synthesis and Properties of 2,3-Dihydroimidazo-and 2,3,4,10-Tetrahydropyrimido[1,2-a]Benzimidazol-9(10)-Ylacetic Acids

  • V. A. AnisimovaEmail author
  • I. E. Tolpygin
  • O. I. Askalepova

Reaction of unsubstituted 2,9-dihydro-3H-imidazo- and 2,3,4,10-tetrahydropyrimido[1,2-a]benz-imidazoles with haloacetates has given hetaryl-9(10)-acetates. The basic and acid hydrolysis of these esters yields the corresponding acids. The zwitterionic structure of the acids obtained has been proved. They were also prepared by the direct alkylation of unsubstituted azaheterocycles using sodium chloroacetate or by hydrolysis of the corresponding acetonitriles. The synthesized esters readily undergo aminolysis and hydrazinolysis.


amides betaines 2,9-dihydro-3H-imidazo[1,2-a]benzimidazoles hetarylacetic acids hydrazides 2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoles basicity protolytic equilibrium 


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • V. A. Anisimova
    • 1
    Email author
  • I. E. Tolpygin
    • 1
  • O. I. Askalepova
    • 2
  1. 1.Scientific-Research Institute of Physical and Organic ChemistrySouthern Federal UniversityRostov-on-the-DonRussia
  2. 2.Chemistry FacultySouthern Federal UniversityRostov-on-the-DonRussia

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