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Synthesis and chemical properties of new derivatives of 3a',6a'-dihydro-2'H-spiro- [indole-3,1'-pyrrolo[3,4-c]pyrrole]-2,4',6'(1H,3'H,5'H)-trione

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Chemistry of Heterocyclic Compounds Aims and scope

A series of new 3a',6a'-dihydro-2'H-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrole]-2,4',6'(1H,3'H,5'H)- triones has been synthesized by cycloaddition of azomethine ylides, obtained from isatins and acyclic aliphatic and sulfur-containing α-amino acids, to maleimides. The direction of the cycloaddition was determined and the chemical properties of the obtained spiro products were examined.

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Notes

  1. Here and subsequently, * in the description of compounds 5a-v, 6a,b indicates what alcohol was used in the synthesis.

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Authors and Affiliations

  1. State Scientfic Institution “Institute for Single Crystals” of National Academy of Sciences of Ukraine, 60 Lenin Ave., Kharkiv, 61001, Ukraine

    T. L. Pavlovskaya, F. G. Yaremenko, S. V. Shishkina, O. V. Shishkin, V. I. Musatov & V. V. Lipson

  2. State Institution “V. J. Danilevsky Institute of Problems of Endocrine Pathology of the Academy of Medical Sciences of Ukraine”, 10 Artema St., Kharkiv, 61002, Ukraine

    R. G. Red’kin, F. G. Yaremenko & V. V. Lipson

  3. V. N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv, 61022, Ukraine

    O. V. Shishkin & V. V. Lipson

Authors
  1. T. L. Pavlovskaya
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  2. R. G. Red’kin
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  3. F. G. Yaremenko
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  4. S. V. Shishkina
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  5. O. V. Shishkin
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  6. V. I. Musatov
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  7. V. V. Lipson
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Correspondence to V. V. Lipson.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 945-960, June, 2013.

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Pavlovskaya, T.L., Red’kin, R.G., Yaremenko, F.G. et al. Synthesis and chemical properties of new derivatives of 3a',6a'-dihydro-2'H-spiro- [indole-3,1'-pyrrolo[3,4-c]pyrrole]-2,4',6'(1H,3'H,5'H)-trione. Chem Heterocycl Comp 49, 882–896 (2013). https://doi.org/10.1007/s10593-013-1322-1

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  • DOI: https://doi.org/10.1007/s10593-013-1322-1

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