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Intramolecular carbonyl nitroso ene reaction: recent developments

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Chemistry of Heterocyclic Compounds Aims and scope

Novel single-step protocols for intramolecular oxidative cyclization of unsaturated hydroxamic acids proceeding by the carbonyl nitroso ene reaction were reported. The reaction can be viewed as a formal intramolecular allylic C–H amination. Simple, mild catalytic system based either on CuCl–O2 in THF or FeCl3–H2O2 in 2-propanol do not adversely affect the transient nitroso species and allow the nitroso ene reaction to take place.

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Correspondence to A. V. Malkov.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 44-48, January, 2012.

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Malkov, A.V. Intramolecular carbonyl nitroso ene reaction: recent developments. Chem Heterocycl Comp 48, 39–43 (2012).

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