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Polarographic investigation of the metronidazole complex with polyvinylpyrrolidone*

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Chemistry of Heterocyclic Compounds Aims and scope

Polarographic behavior of the metronidazole complex with polyvinylpyrrolidone in Britton-Robinson buffer solutions have been studied. This complex possesses prolonged antimicrobial action. Complexation with polyvinylpyrrolidone was shown to alter the mechanism of metronidazole reduction and increases its solubility in water. The temperature dependence of the limiting currents indicates the formation of additional hydrogen bonds in the complex, which restricts diffusion of the depolarizer to the cathode.

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The authors thank L. G. Rozinova for supplying samples for study and assistance in preparing the experiments.

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Authors and Affiliations

  1. A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 1 Favorsky St., Irkutsk, 664033, Russia

    T. I. Vakulˈskaya, L. I. Larina & V. A. Lopyrev

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  1. T. I. Vakulˈskaya
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  2. L. I. Larina
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  3. V. A. Lopyrev
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Correspondence to T. I. Vakulˈskaya.

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*Dedicated to Academician M. G. Voronkov on his 90th birthday.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1654–1660, November, 2011.

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Vakulˈskaya, T.I., Larina, L.I. & Lopyrev, V.A. Polarographic investigation of the metronidazole complex with polyvinylpyrrolidone*. Chem Heterocycl Comp 47, 1372–1377 (2012). https://doi.org/10.1007/s10593-012-0923-4

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  • DOI: https://doi.org/10.1007/s10593-012-0923-4

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