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Synthesis of novel 1,3,4-oxadiazole derivatives and their nucleoside analogs with antioxidant and antitumor activities

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Chemistry of Heterocyclic Compounds Aims and scope

A series of new (1,3,4-oxadiazol-2-yl)-1H-benzo[h]quinolin-4-one derivatives were synthesized, including glucose and xylose hydrazones that were obtained by the reaction of hydrazides with monosaccharides. Cyclization of the sugar hydrazones with acetic anhydride afforded substituted oxadiazoline derivatives. The newly synthesized compounds were evaluated for their antioxidant properties and cytotoxicity, and showed moderate to high activities.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt

    A. A. Fadda & T. A. Zidan

  2. Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Koam, Egypt

    A. A.-H. Abdel-Rahman

  3. Department of Photochemistry, National Research Center, El-Dokki, Cairo, Egypt

    W. A. El-Sayed

  4. Department of Drugs, Faculty of Pharmacology, Mansoura University, Mansoura, Egypt

    F. A. Badria

Authors
  1. A. A. Fadda
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  2. A. A.-H. Abdel-Rahman
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  3. W. A. El-Sayed
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  4. T. A. Zidan
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  5. F. A. Badria
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Corresponding author

Correspondence to A. A.-H. Abdel-Rahman.

Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1045–1054, July, 2011.

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Fadda, A.A., Abdel-Rahman, A.AH., El-Sayed, W.A. et al. Synthesis of novel 1,3,4-oxadiazole derivatives and their nucleoside analogs with antioxidant and antitumor activities. Chem Heterocycl Comp 47, 856–864 (2011). https://doi.org/10.1007/s10593-011-0847-4

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  • DOI: https://doi.org/10.1007/s10593-011-0847-4

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