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Reaction of 2-hetaryl-2-(tetrahydro-2-furanylidene)acetonitriles with aldehydes

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Chemistry of Heterocyclic Compounds Aims and scope

The reaction of 2-hetaryl-2-(tetrahydro-2-furanylidene)acetonitriles with a electrophilic reagent (anisaldehyde) was studied. It was shown that condensation of the latter with 2-(4-oxo-3,4-dihydro-2-quinazolyl)- and 2-(1H-benzo[d]imidazol-2-yl)-2-(tetrahydro-2-furanylidene)acetonitriles in the presence of secondary amines or acids takes place with elimination of the furan fragment and the formation of 3-aryl-2-(4-oxo-3,4-dihydro-2-quinazolinyl)- and 2-(1H-benzo[d]imidazol-2-yl)acrylo-nitriles.

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Correspondence to O. V. Khilya.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1157-1161, August, 2010.

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Khilya, O.V., Baglay, Y.V. & Volovenko, Y.M. Reaction of 2-hetaryl-2-(tetrahydro-2-furanylidene)acetonitriles with aldehydes. Chem Heterocycl Comp 46, 934–937 (2010).

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