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Chemistry of Heterocyclic Compounds

, Volume 46, Issue 4, pp 495–499 | Cite as

Synthesis of heterocycles on the basis of products of arylation of unsaturated compounds 22.* 3-Aryl-2-chloropropanal in the synthesis of N-Aryl-5-(R-benzyl)-1,3-thiazole-2-amines

  • V. S. Matiychuk
  • N. D.ObushakEmail author
  • N. I. Pidlypnyi
  • Yu. V. Ostapiuk
  • R. M. Voloshchuk
Article

3-Aryl-2-chloropropanal was obtained by the reaction of arenediazonium chlorides with acrolein in the presence of copper(II) chloride. N-Aryl(2-pyridyl)-5-(R-benzyl)-1,3-thiazole-2-amines were formed in high yield by the reaction of these aldehydes with aryl- and 2-pyridylthioureas. The same compounds were obtained by the reaction of 5-(R-benzyl)-1,3-thiazole-2-amines with aniline.

Keywords

2-aminothiazoles arylthioureas derivatives of thiazole α-chloro aldehydes arylation the Meerwein reaction 

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Copyright information

© Springer Science+Business Media, Inc. 2010

Authors and Affiliations

  • V. S. Matiychuk
    • 1
  • N. D.Obushak
    • 1
    Email author
  • N. I. Pidlypnyi
    • 1
  • Yu. V. Ostapiuk
    • 1
  • R. M. Voloshchuk
    • 1
  1. 1.Ivan Franko Lviv National UniversityLvivUkraine

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