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Synthesis of n-aminoglycosides derived from alkaloid cytisine, their biological activity and crystal structure of N-(β-D-galactopyranosyl)cytisine

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Chemistry of Heterocyclic Compounds Aims and scope

Optimal conditions were found for the synthesis of a number of new N-aminoglycosides of the alkaloid cytisine, using commercially available monosaccharides, namely, D-glucose, D-galactose, D-xylose, and L-arabinose. X-ray structural analysis indicated an absolute β-anomeric configuration of N-(β-D-galactopyranosyl)cytisine in the crystalline state. The comparative cytotoxicity of cytisine and some of its N-aminoglycosides was determined.

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Correspondence to I. V. Kulakov.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 300-305, February, 2010.

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Kulakov, I.V., Nurkenov, O.A., Turdybekov, D.M. et al. Synthesis of n-aminoglycosides derived from alkaloid cytisine, their biological activity and crystal structure of N-(β-D-galactopyranosyl)cytisine. Chem Heterocycl Comp 46, 240–244 (2010).

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