Chemistry of Heterocyclic Compounds

, Volume 46, Issue 1, pp 50–55 | Cite as

Synthesis of heterocycles on the basis of arylation products of unsaturated compounds. 19.* Arylation of 2-acetylthio- phene and the synthesis of 2-(5-aryl-2-thien- yl)-4-quinolinecarboxylic acids

  • V. S. Matiychuk
  • N. D. ObushakEmail author
  • R. Z. Lytvyn
  • Yu. I. Horak

The reaction of 2-acetylthiophene with acetylthiophene with arenediazonium chlorides in the presence of cupric chloride as catalyst gives 2-acetyl-5-arylthiophenes. These products react with 5-chloro- and 5-bromoisatins to give 6-chloro- and 6-bromo-substituted 2-(5-aryl-2-thienyl)-4-quinolinecarboxylic acids.


2-acetyl-5-arylthiophenes 2-acetylthiophene 4-quinolinecarboxylic acid derivatives arylation Meerwein reaction Pfitzinger reaction 


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Copyright information

© Springer Science+Business Media, Inc. 2010

Authors and Affiliations

  • V. S. Matiychuk
    • 1
  • N. D. Obushak
    • 1
    Email author
  • R. Z. Lytvyn
    • 1
  • Yu. I. Horak
    • 1
  1. 1.Ivan Franko Lviv National UniversityLvivUkraine

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