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Efficient solid-phase synthesis of isocytosine derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

We have investigated the potential use of a solid-phase synthesis of novel 6-(arylmethyl)-5-methyl-isocytosine derivatives based on the immobilization of the corresponding 2-thiothymine on a Merrifield resin, oxidation of the immobilized form to the sulfone, and aminolysis of the latter under mild conditions.

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Authors and Affiliations

  1. Volgograd State Technical University, Volgograd, 400131, Russia

    I. A. Novakov, B. S. Orlinson, R. V. Brunilin, M. B. Nawrozkij, E. A. Gordeeva, E. N. Savel‘ev & E. N. Gerasimov

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  1. I. A. Novakov
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  2. B. S. Orlinson
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  3. R. V. Brunilin
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  4. M. B. Nawrozkij
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  5. E. A. Gordeeva
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  6. E. N. Savel‘ev
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  7. E. N. Gerasimov
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Corresponding author

Correspondence to M. B. Nawrozkij.

Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1697-1702, November, 2009.

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Novakov, I.A., Orlinson, B.S., Brunilin, R.V. et al. Efficient solid-phase synthesis of isocytosine derivatives. Chem Heterocycl Comp 45, 1365–1369 (2009). https://doi.org/10.1007/s10593-010-0434-0

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  • DOI: https://doi.org/10.1007/s10593-010-0434-0

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