4-Acetyl-5,6-diphenylpyridazin-3(2H)-one was condensed with 6-chloro-3-formylchromone under different reaction conditions to yield the enone or pyranopyridazine. Both compounds were used in the synthesis of some new hetarylpyranopyridazines. Pyranodipyridazine was obtained via a sequence of reactions of 4-acetyl-5,6-diphenylpyridazin-3(2H)-one with diethyl carbonate, acetic anhydride, and 4-bromobenzenediazonium chloride. The reactions of pyridazinylbutane-1,3-dione with conc. H2SO4, POCl3, hydrazines, hydroxylamine hydrochloride, cyanoacetamide, thiourea, and thiosemicarbazone were also studied.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1684–1696, November, 2009.
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Abdel-Megid, M., Gabr, Y., Awas, M.A.A. et al. Synthesis of some new hetarylpyranopyridazines, cinnolines, and hetarylpyridazine derivatives. Chem Heterocycl Comp 45, 1354–1364 (2009). https://doi.org/10.1007/s10593-010-0433-1
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DOI: https://doi.org/10.1007/s10593-010-0433-1