Chemistry of Heterocyclic Compounds

, Volume 45, Issue 2, pp 215–218 | Cite as

Synthesis of substituted 1,3,4-oxadiazole derivatives

  • V. MickevičiusEmail author
  • R. Vaickelionienė
  • B. Sapijanskaitė

Monosubstituted oxadiazoles were synthesized by the reaction of hydrazides with triethyl orthoformate. Their reactions with benzoyl chloride gave benzoylcarbohydrazides, which under the action of thionyl chloride were cyclized to the respective 2,5-disubstituted oxadiazoles. 1-Aryl-4-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-pyrrolidin-2-ones were synthesized from acid hydrazides using carbon disulfide under basic conditions.


acid hydrazides benzoyl chloride 2-pyrrolidinone substituted oxadiazoles thionyl chloride 5-thioxo-1,3,4-oxadiazoles 


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Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  • V. Mickevičius
    • 1
    Email author
  • R. Vaickelionienė
    • 1
  • B. Sapijanskaitė
    • 1
  1. 1.Kaunas University of TechnologyKaunasLithuania

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