A novel route is proposed for the synthesis of heterocyclic analogs of the naturally occurring combretastatin A-4 based on the reaction of α-acetylenic ketones with polyfunctional nucleophiles (hydroxylamine, hydrazine, guanidine). Previously unknown combretastatin A-4 analogs with azole and azine bridges were obtained.
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Dedicated to Academician of the Russian Academy of Sciences B. A. Trofimov on his 70th jubilee.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1545–1549, October, 2008.
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Vasilevsky, S.F., Davydova, M.P. & Tolstikov, G.A. Heterocyclic analogs of combretastatin A-4. Chem Heterocycl Comp 44, 1257–1261 (2008). https://doi.org/10.1007/s10593-009-0171-4
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DOI: https://doi.org/10.1007/s10593-009-0171-4